government site. Pregnancy:Data on the use of isosorbide mononitrate during pregnancy are insufficient to be able to assess the possible harmful effect. Then, there was a two-week placebo washout, after which the alternative treatment was given. Does isosorbide mononitrate (Monoket) lower blood pressure? Imdur (isosorbide mononitrate) Extended Release and Isordil (isosorbide dinitrate) are vasodilators indicated for the prevention of angina pectoris due to coronary artery disease.. Side effects of Imdur and Isordil that are similar include headache and dizziness.. Side effects of Isordil that are different from Imdur include weakness and skin changes such as redness, tingling, or warmth. Isosorbide can only be used to prevent angina; it cannot be used to treat an episode of angina once it has begun. Whenever you take more than one medicine, or mix it with certain foods or beverages, you"re at risk of a drug interaction. Normal ecg doesn't rule out heart disease. Aspirin has an average rating of Be sure to talk to your health care provider before you take any herbal supplements if you take prescription medicines. https://naturalmedicines.therapeuticresearch.com. Medicines Complete BNF 84th Edition; British Medical Association and Royal Pharmaceutical Society of Great Britain, London. Healthcare data is obtained from a number of sources including the Food and Drug Administration (FDA). Methods: Erectile dysfunction medications (e.g., sildenafil (Viagra), vardenafil (Levitra), tadalafil (Cialis)) cannot be taken while you're taking isosorbide mononitrate (Monoket). Do not take a double dose to make up for a missed one. To view a report comparing 3 (or more) medications, please sign in or create an account. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Lifestyle changes such as dietary changes, exercise, and not smoking may help this drug work better. Cleophas TJ, Niemeyer MG, Zwinderman AH, van der Wall EE. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Some conditions may become worse when the drug is suddenly stopped. In: Current Medical Diagnosis & Treatment 2022. In Canada - Call your doctor for medical advice about side effects. Accessed Sept. 7, 2022. Isosorbide mononitrate is a nitrate-class drug used for the prophylactic treatment of angina pectoris; that is, it is taken in order to prevent or at least reduce the occurrence of angina. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. If tolerance is suspected during the use of transdermal patches they should be left off for 8-12 hours (usually overnight) in each 24 hours; in the case of modified-release tablets of isosorbide dinitrate (and . The herb licorice may lower warfarin levels and can add to digoxin's effects. You may report side effects to the FDA at 1-800-FDA-1088. Isosorbide immediate-release tablets are used for the management of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). Patient is a UK registered trade mark. The most common side-effect is headache. Isosorbide mononitrate: isosorbide mononitrate. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. Almost 70% of older adults use them. The drug donates nitric oxide to the body, which is similar to all other Isosorbide mononitrates. Garlic. Limited data from animal studies indicate no adverse effects on the pregnancy or the unborn child. privacy practices. I would rather take the chance of a heart attack than have no quality of life. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. The use of the Truven Health products is at your sole risk. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. isosorbide mononitrate prices. Do not take more or less of it or take it more often than prescribed by your doctor. May also be prescribed off label for Esophageal Spasm. Isosorbide mononitrate (Monoket) is not known to affect the kidneys. Available for Android and iOS devices. Reduction of blood-nitrate concentrations to low levels for 4 to 12 hours each day usually maintains effectiveness in such patients. Drug information provided by: IBM Micromedex. We asked 34 people what they think about isosorbide mononitrate (Monoket): Get Isosorbide mononitrate (Monoket) for as low as $29.86, 180 tablets of isosorbide mononitrate 10mg. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Along with its needed effects, a medicine may cause some unwanted effects. coma (loss of consciousness for a period of time). https://naturalmedicines.therapeuticresearch.com. My blood pressure, cholesterol and pulse are all normal and I have no chest pains, shortness of breath or other heart problem symptoms. Do not share this medication with others. Registered in England and Wales. What are the side effects of Isosorbide Mononitrate ? Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Conclusions: Click here for an email preview. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). You may opt-out of email communications at any time by clicking on The information on this page is written and peer reviewed by qualified clinicians. We don't support your browser. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload. Aspirin relieves pain and inflammation and helps to thin the blood. eCollection 2021. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle. If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice. 72% of reviewers reported a positive effect, while 12% reported a negative effect. Isosorbide mononitrate is very similar to isosorbide dinitrate. Limit alcoholic beverages. you should know that isosorbide may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. When used regularly on a long-term basis, this helps prevent angina attacks from occurring. Ask your pharmacist for a list of the ingredients. Don't drink alcohol while taking isosorbide mononitrate (Monoket). US residents can call their local poison control center at 1-800-222-1222. Severe postural hypotension with light-headedness and dizziness is frequently observed after the consumption of alcohol. If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia). daily and increasing to 40 mg three times daily as necessary, given at 8 AM, 1 PM, and 6 PM), isosorbide mononitrate (starting at 30 mg/day in the morning and increasing to 120 mg/day as necessary), or a transdermal. Nitrate-Induced Headache in Patients with Stable Angina Pectoris: Beneficial Effect of Starting on a Low Dosage. Natural Medicines. Bookshelf It can make you really dizzy. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. (3) The overall number of headache attacks in the first period of active treatment was significantly higher than in the second period irrespective of the dosages given. It is important to take the drug at the same times each day. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Use of herbal products and potential interactions in patients with cardiovascular diseases. Isosorbide mononitrate Alternatives Compared Isosorbide mononitrate Aspirin Nitroglycerin Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Commonly reported side effects include: See also: isosorbide mononitrate side effects in more detail. Synthroid (levothyroxine) Tylenol (acetaminophen) Vitamin B12 (cyanocobalamin) Vitamin C (ascorbic acid) Vitamin D3 (cholecalciferol) Isosorbide mononitrate disease interactions There are 7 disease interactions with isosorbide mononitrate which include: AMI anemia hemodialysis hypotension intracranial pressure hypertrophic cardiomyopathy glaucoma This is called tolerance, and it cannot be fixed by raising the dose of the medication. It is not intended as medical advice for individual conditions or treatment. Always consult your healthcare provider. Isosorbide tablets are also used with other medications to treat heart failure. Isosorbide mononitrate, sold under many brand names, is a medication used for heart-related chest pain ( angina ), heart failure and esophageal spasms. If you miss a dose, take it as soon as you remember. Isosorbide extended-release (long-acting) tablets and extended-release capsules are used for the management of chest pain in people who have coronary artery disease. Do not change the dosing times unless directed by your doctor. It took me a few weeks to adapt to it, but the effect on preventing chest pain was dramatic. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. Do infrared saunas have any health benefits? You can take your doses either before or after meals. McGraw Hill; 2022. https://accessmedicine.mhmedical.com/search. Some side effects may occur that usually do not need medical attention. Journal of the American College of Cardiology. To provide you with the most relevant and helpful information, and understand which It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means. Diabetes treatment: Can cinnamon lower blood sugar? Accessed Sept. 7, 2022. Let your provider know if they are excessive. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Take extra precautions to avoid falling during your treatment with isosorbide. . These headaches may be a sign that the medication is working as it should. amlodipine, lisinopril, aspirin, metoprolol, furosemide, carvedilol, propranolol, spironolactone, atenolol, diltiazem. What conditions does Isosorbide Mononitrate treat? Please enable it to take advantage of the complete set of features! When used regularly on a long-term basis, this helps prevent angina attacks from occurring. While both isosorbide mononitrate (Monoket) and nitroglycerin (Nitrostat) are both nitrate vasodilators, they are not the same medication. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. These side effects may go away during treatment as your body adjusts to the medicine. (1) Starting on a low dosage was associated with a reduced frequency and severity of headache and did not notably influence the beneficial effect on angina pectoris. Isosorbide mononitrate (Monoket) can cause some serious health issues. 2006 Apr;95(4):217-23. doi: 10.1007/s00392-006-0367-x. 1998 Oct;61(10):577-83. See the full pregnancy warnings document. Unauthorized use of these marks is strictly prohibited. 2017; doi:10.1016/j.jacc.2016.11.078. It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as glyceryl trinitrate (GTN), for if you get angina pain. from the best health experts in the business. Cardizem may also be used for purposes not listed in this medication guide. May also be prescribed off label for Esophageal Spasm. Changing positions slowly can help lessen dizziness. Take them to your local pharmacy which will dispose of them for you. If this worries you, talk to your doctor or pharmacist about other options. Would you like email updates of new search results? Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. The Swedish Multicentre Group. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Seek alternatives to the CYP3A4 substrate when possible. Nitrates in the management of acute coronary syndrome. 41% of reviewers reported a positive effect, while 50% reported a negative effect. It is used to treat and prevent a wide range of different conditions. Natural Medicines. Accessed Sept. 7, 2022. We comply with the HONcode standard for trustworthy health information. PMC Select a condition to view a list of medication options. All rights reserved. It is important that you follow the instructions your doctor gives to you about when to take your doses. May also be prescribed off label for Esophageal Spasm. 8600 Rockville Pike Isosorbide may cause other side effects. You need to take it every day in order for it to work. With any medication, there are risks and benefits. Stopping isosorbide mononitrate (Monoket) suddenly can cause you to have a worsening of your chest pain. There are a number of medications that your doctor can prescribe in place of isosorbide mononitrate (Monoket). B complex. 46 ratings on Drugs.com. All rights reserved. Portions of this document last updated: Feb. 01, 2023. Pricing based on most commonly-filled versions: 180 tablets of isosorbide mononitrate 10mg. FOIA AHFS Patient Medication Information. Change positions slowly until your body is used to the medication. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Natural Medicines. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Talk to your doctor about the possible risks of using this medication for your condition. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Valerian: A safe and effective herbal sleep aid? Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less commonAcid or sour stomachanxietyback painbelchingblemishes on the skinbloatedbreast painburning feeling in the chest or stomachburning, dry, or itching eyeschange in color visionchanges in visioncold sweatscongestionconstipationcontinuing ringing or buzzing or other unexplained noise in the earscough producing mucusdecreased interest in sexual intercoursedifficulty seeing at nightdifficulty with movingdischarge, excessive tearingdouble visiondrooping upper eyelidsdull ache or feeling of pressure or heaviness in the legsearacheexcess air or gas in the stomach or intestinesfeeling of constant movement of self or surroundingsfeeling of warmthfeeling unusually coldfrequent urge to defecatefrozen shoulderfull feelinghearing lossheartburnhyperventilationinability to have or keep an erectionincreased appetiteincreased sensitivity of the eyes to sunlightincreased sputumindigestionirritabilityitching skin near damaged veinslack or loss of strengthloss in sexual ability, desire, drive, or performancemuscle or bone painmuscle stiffness or weaknessnightmaresnoisy breathingpain or tenderness around the eyes and cheekbonespassing gaspimplespoor concentrationrashredness of the face, neck, arms, and occasionally, upper chestredness, pain, swelling of the eye, eyelid, or inner lining of the eyelidredness, swelling, or soreness of the tonguerestlessnessseeing doublesensation of spinningsleepiness or unusual drowsinesssmall clicking, bubbling, or rattling sounds in the lung when listening with a stethoscopesmall lumps under the skinsore mouth or tonguestiff neckstomach bloating, burning, cramping, or painstomach discomfort or upsetstraining while passing stoolstuffy nosesudden sweatingswollen feet and anklestender, swollen glands in the necktenderness in the stomach areaterrifying dreams causing sleep disturbancestooth disordertrouble swallowinguncontrolled twisting movements of the neckvoice changesweight losswhite patches in the mouth, tongue, or throatOther side effects not listed may also occur in some patients. Which drugs or supplements interact with isosorbide mononitrate? Thirty percent of the patients never experienced headache from the given dosages. Disclaimer. Do not let anyone else take your medication. Moderately clinically significant. Licorice. Isosorbide mononitrate dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.Isosorbide mononitrate is used to prevent angina attacks (chest pain). Who should not take Isosorbide Mononitrate? Many people using this medication do not have serious side effects. Murray MT. Isosorbide dinitrate (Isordil) is available as both a short-acting tablet and long-acting capsule. In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Lyrica and Metoclopramide drug interaction, Calcitriol and Metoclopramide drug interaction. It works to relax your blood vessels. Isosorbide mononitrate helps to prevent angina chest pain from developing. Profen and Metoclopramide drug interaction, Metoclopramide and Nitrostat drug interaction, Metoclopramide and Alfentanil drug interaction, Risperdal and Metoclopramide drug interaction. All rights reserved. URL of this page: https://medlineplus.gov/druginfo/meds/a682348.html. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. This medicine is a white, round, scored, tablet imprinted with "KU 107" and "20". Liperoti R, et al. Isosorbide (C6H10O4), also called D-Isosorbide dinitrate, is a bio-product sourced from starch. A single copy of these materials may be reprinted for noncommercial personal use only. Tolerance is more likely to happen if you don't take your dose at the same time every day. Methods: In a randomized, double-blind, crossover study, 89 patients with stable angina pectoris were studied to compare two different dosage strategies of isosorbide-5-mononitrate (5-ISMN). Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. Includes Isosorbide Mononitrate indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). Cao HY, Wu HD, Song ZK, Tang ML, Yang S, Liu Y, Qin L. Pan Afr Med J. All rights reserved. Contact your provider right away if you feel as if you are going to pass out and are experiencing an irregular heartbeat, nausea, vomiting, changes in vision, more sweating, or cold and clammy skin. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Instead, the best way to dispose of your medication is through a medicine take-back program. Canada residents can call a provincial poison control center. People with kidney problems should be able to take the usual dose of isosorbide mononitrate (Monoket). Elantan, Imdur, Isotard, Monomax, Tardisc, Xismox. Take your next dose at the regular time. Contact your doctor immediately if you experience any of the following: The following side effects may get better over time as your body gets used to the medication. Please note that only the generic name of each medication is listed below. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Do not try to change the times or the way that you take isosorbide in order to avoid headaches because then the medication may not work as well. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Prescription only Prescribed for Angina, Heart Failure, Angina Pectoris Prophylaxis. Does isosorbide mononitrate (Monoket) affect your kidneys? The table below contains some of the most common ones associated with isosorbide mononitrate. information submitted for this request. Dated August 2017. Watch for any symptoms that you may be having a drug interaction, such as: Mayo Clinic does not endorse companies or products. It works by . We study millions of patients and 5,000 more each day. Talk to your doctor or pharmacist about lifestyle changes that might benefit you. Mehta D. Herbal & dietary supplements. MeSH As precautionary measure, breast-feeding should be discontinued during treatment with isosorbide mononitrate. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. But only about 25% of people who take herbal supplements tell their health care providers. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Isosorbide mononitrate 30% immediate-release 70% sustained-release formulation: a review. National Library of Medicine This should pass after a few days. Melanoma is one of the most dangerous forms of skin cancer which develops in the skin cells that produce melanin ( the pigment that gives your skin its color). information is beneficial, we may combine your email and website usage information with Now, youll enjoy a streamlined experience created specifically for healthcare providers. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Taking erectile dysfunction medications or drinking alcohol while taking isosorbide mononitrate (Monoket) can cause your blood pressure to get dangerously low, which can be life-threatening. This medicine is available only with your doctor's . Some of these medicine interactions can be risky. This product may contain inactive ingredients, which can cause allergic reactions or other problems. information highlighted below and resubmit the form. Keep all medicines out of the reach and sight of children. Good at preventing chest pain caused by heart disease, Available as a generic version, making it less expensive, Long-acting version only needs to be taken once daily, Short-acting tablets have to be taken on a very specific schedule for the medication to work best. Some of the common derivatives include isosorbide dinitrate and isosorbide mononitrate, which are . This product is available in the following dosage forms: There is a problem with 67% of reviewers reported a positive effect, while 13% reported a negative effect. It is unknown if this medication passes into breast milk. Yet significantly fewer patients had headache on low dosage than on high dosage (45 vs 57, P < 0.02). On the other hand, the ER version can only help prevent angina. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips. 7.6 out of 10 from a total of Talk to your pharmacist for more details. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. The https:// ensures that you are connecting to the Using this medicine with any of the following medicines is not recommended. Danshen can interact strongly with some heart medicines, such as: Evening primrose may raise your risk of bleeding if you also take a blood thinner, such as: Garlic may raise your risk of bleeding if you also take a blood thinner, such as: Ginkgo biloba may raise your risk of bleeding if you also take a blood thinner, such as: If you take ginseng with warfarin, it may lessen how well warfarin works. Enter other medications to view a detailed report. This is not a complete list of possible side effects. If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Please upgrade your browser or download modern browsers from here! Isosorbide mononitrate (Monoket) is good for a specific type of chest pain (called angina), but it can cause headaches or dizziness after you take it. https://naturalmedicines.therapeuticresearch.com. Medicines containing Isosorbide Mononitrate. This information is aggregated and used to produce personalized reports that patients can reference. Accessed Sept. 7, 2022. This should pass after a few days. You may report side effects to Health Canada at 1-866-234-2345. There are no data on passage of isosorbide mononitrate in human milk, but some excretion seems likely. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Isosorbide mononitrate (Monoket) is available as both a immediate-release (IR, short-acting) and extended-release (ER, long-acting) tablet. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, excess air or gas in the stomach or intestines, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, stomach bloating, burning, cramping, or pain, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. 88 ratings on Drugs.com. Herbal supplements can strongly affect the body. Does Viagra add to the risks of melanoma? Clipboard, Search History, and several other advanced features are temporarily unavailable. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.