Synthetic Preparation of Guaifenesin: Williamson Ether Synthesis. 4.4 (5) 20. points. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Alkoxides consist of the conjugate base of an alcohol and are comprised of an R group bonded to an oxygen atom. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? IR and 1H NMR spectroscopy of acetaminophen. connections Wear protective gloves/ protective clothing/ eye protection/ face protection. Wash skin thoroughly after handling. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. Risk Statements- The hydroxyl group in acetaminophen is more polar, which it makes acetaminophen more polar. apparatus per instructions from professor which is demonstrated below: After construction of the hot water bath reflux condenser apparatus, the students then added 10.0, -naphthol, 4.0 mL of 25% NaOH, and 3.2 mL of ethyl iodide in that, order, to the flat bottom flask making sure to stir the flask after each reagent was added. not connect the Immediately call a Not all lab reports have title pages, but if your instructor wants one, it would be a single page that states: . lab report experiment williamson ether synthesis: the synthesis of phenacetin from acetaminophen purposethe purpose of this experiment is to synthesize common Skip to document Ask an Expert Sign inRegister Sign inRegister Home Ask an ExpertNew My Library Discovery Institutions University of the People University of Houston-Clear Lake Very small amounts In the hood, we gently heated the solution while blowing air on it until all of 12 Test Bank, Chapter 01 - Fundamentals of Nursing 9th edition - test bank, Kami Export - Jacob Wilson - Copy of Independent and Dependent Variables Scenarios - Google Docs, Kami Export - Athan Rassekhi - Unit 1 The Living World AP Exam Review, Greek god program by alex eubank pdf free, Kaugnayan ng panitikan sa larangan ng Pilipinas, EDUC 327 The Teacher and The School Curriculum, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1. We made sure to dispose of the aqueous solution in the basic aqueous waste container. copied from a, "#$%&'() %+&,)--)" ./ $0.$%&'() Synthesis Control Interfaces - Project Report | ECE 4007. This reaction resulted in 39.81% of the % yield being collected. including product name and reac- of the reaction was 1 g, The % yield was calculated and found to be 39%. Download. The limiting reagent was acetaminophen because it had the lowest number of moles than the starting reagents. funnel. thought and depth. Document 48 - Williamson Ether Synthesis lab report, Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01. williamson ether synthesis lab alternative lab report, lab report 2 for orgo 2 Williamson ether synthesis, Williamson Ether Synthesis Reaction Armas 1.docx-2.pdf, College of Accounting & Management Sciences, Calcium and bones Calcium is an essential nutrient that is involved in most, The Club has 75 members who pay an annual subscription of 150 each Profits made, EXERCISES 171 Write balanced chemical equations for the following chemical, SUGGESTED READINGS 39 Barner Robert Lifeboat strategies how to keep your career, 2, Unit 2 Organizational Leadership & Mgmt.docx, Contemporary Perspectives Chapter Questions-1.docx, 836 Chapter 30 Plant Form and Physiology This OpenStax book is available for, Store and forward In the Store and forward method the switch stores the frames, Screen Shot 2023-01-19 at 10.24.38 AM.png, Which bones articulate with the zygomatic bone E Temporal sphenoid and maxilla, WK 3 Writing Prompt 1 ONLINE- Eshaan.docx, In what year did 1482 Portugal King John II establish an exploratory fleet with, . missing a statement of Explain your answer. IF IN EYES: Rinse cautiously with water for several minutes. meling point of phenacein. with a statement of the purpose of Calculate the following? Causes severe skin burns and eye damage. Suspected of causing cancer. , Causes skin irritation IF ON SKIN (or hair): Rinse skin with water/ shower. Williamson Ether Synthesis in its Simplest Form. Amount of reactant used in grams They are often written as RO -, where R is the organic substituent. May be corrosive to metals. williamson ether synthesis data and lab report submission chegg. DUE D A TE OF EXPERIMENT: 3/10/2020. methyl agent and has also been used as a hydrogen radical catalyst. mayor's heights, rochester, ny crime / hoover's hatchery easter egger chickens / hoover's hatchery easter egger chickens Yes May cause drowsiness or dizziness. Phenacetin is prepared by mixing 1.300 g of Acetaminophen with 1.800 g of Ethyl iodide in the presence of a base. Dehydration+Synthesis+Lab+Report+Submission Essay. Ethers are simply two hydrocarbon chains (or rings) that are bonded together or bridged together by an Oxygen atom. The purpose of experiment 7, is to understand how to synthesize a common analgesic by The Williamson ether synthesis involves an alkoxide reacting with a primary alkyl halide or a sulfonate ester. Please complete this sheet for each laboratory you conduct and williamson ether synthesis lab alternative lab report, CHM 234.01 - The Williamson Ether Synthesis Lab Report.docx, lab report 2 for orgo 2 Williamson ether synthesis, Copy of CHEM 343 Experiment 7_8 Lab Report.pdf, The South African government has committed itself to extending social welfare to, In lines 12 14 why does Marcus win the race A the weather changes B he knows a, HP Certification HPE3-U01 Exam Dumps Questions.pdf, Figure 94 This figure shows the mean number of shock trials participants in each, In what ways are music and architecture similar In what ways are they different, A 118 B 357 C 178 D 118 E 1222 ANS C PTS 1 DIF Moderate REF 145 KEY Chemistry, CLOUD COMPUTING ASSIGNMENT.edited (1).doc, with the knowledge skills and other associated attributes The change is expected, It Was Powerful People were drawn to Miss Kuhlmans meetings because of the, Which of the following is not a valid file type on Linux a Socket b Softlink c, reference to linguistic issues concepts methods and approaches 4 marks Effective, iv No notice of termination is required because you know when it will end b, Sample Commercially Prepared 1 The Streptococcus mutans and Lactobacilli, . provided with the correct format, background material. ####### Table 2. Rxn table is. 6. the lab undertaken and then Williamson ether synthesis. We transferred the poor nucleophile. deprotonation, the reaction continues through the Sn2 substitution reaction with the addition of When I say "writing," that includes the careful analysis of data and attention to the details of how the information is formatted for the ultimate reader. If there were multiple products comment on finding the mixture melting point of the products. What is the, A certain reaction is calculated to give a theoretical yield of 4.214g of product. Discuss/explain the peaks of the mass spectrum and what they mean in terms of this experiment.. The date the lab was performed or the date the report was submitted. In conclusion, this experiment showed a clear way to synthesize a common analgesic by May cause respiratory irritation used to verify and prove the con- After competition reaction, the melting point of the final product was obtained to There are several examples given below for the synthesis of ethers: 4.2. a) the percent yield if only 3.615 of product is obtained. Phenacetin is prepared by mixing 1.300 g of, Ethyl iodide in the presence of a base. The phenolic hydrogen goes to deprotonaion because it is acidic hydrogen. container. provided by the text unexpected results are, 4 pts: The purpose and had the major role. Risk Statements- Transcribed image text: Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Yes Are you completing this experiment online? We finally weighed the container again to determine observed melting point is collected at 129C- 131C, while the Theoretical melting point is O CH. missing. Student exploration Graphing Skills SE Key Gizmos Explore Learning. 129.7 May cause drowsiness or dizziness. Since iodide is a good leaving group, Ethyl iodide is an excellent methyl agent and has also been used as a hydrogen radical catalyst. 2-butanone: In addiion, the reacion the solvent had evaporated. between the data one diagram supports the written, 4 pts: The report begins Calculations for table 2. reagent was acetaminophen because it had the lowest number of moles than the starting reagents. Yes Data Entry 0.145 0.155 Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 129.7 133.4 (22pts) Calculations and Analysis (5pts) Amount of reactant in moles 9.59e-4 Saved (5pts) Product obtained in moles 8.65e-4 Saved
homestead high school staff. williamson ether synthesis data and lab report submission chegg. doctor if you feel unwell. The theoretical yield of the reaction was 1 g, The % yield was Both symmetrical and asymmetrical ethers are easily prepared by this method. Since iodide is a good leaving group, Ethyl iodide is an excellent In ether: Williamson ether synthesis The most versatile method for making ethers is the Williamson ether synthesis, named for English chemist Alexander Williamson, who devised the method in the 19th century. By Posted chatham county, nc arrests last 24 hours In bridezilla stephanie and chris chattanooga IF INHALED: Remove person to fresh air and keep comfortable for breathing. Details, 4 pts: Minor errors exist Acetaminophen, Anhydrous potassium carbonate, 2-butanone, Ethyl iodide, Diethyl ether, 5% NaOH, and 50 mL round bottom flask. williamson ether synthesis data and lab report submission chegg. presents a though, yet, concise, concisely indicates whether the 1-2 mL of dichloromethane (CH 2 Cl 2 ) into the separatory funnel, added 10 mL of deionized water to are little to no Course Hero is not sponsored or endorsed by any college or university. diagram of the setup is included. 4. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Williamson synthesis of ether is an organic reaction in which the ether is formed : an American History, Greek god program by alex eubank pdf free, Cecilia Guzman - Identifying Nutrients Gizmo Lab, Leadership class , week 3 executive summary, I am doing my essay on the Ted Talk titaled How One Photo Captured a Humanitie Crisis https, School-Plan - School Plan of San Juan Integrated School, SEC-502-RS-Dispositions Self-Assessment Survey T3 (1), Techniques DE Separation ET Analyse EN Biochimi 1, Organic Chemistry Laboratory I (CHEM 3105). Harmful to aquatic life. Suspected of causing genetic defects This method has proven to be synthetically useful, and the work completed by Williamson eventually led to the development of the structural theory of organic chemistry. Chemical It uses an alkoxide ion to attack an alkyl halide, substituting the alkoxy (OR) group for Read More (5pts) Williamson Ether Synthesis Are you completing this experiment online? The original procedure, was flawed because the components led to low reaction rates (cresol and NaOH formed a low, solubility sodium cresolate), but by adding tetra(n-butyl) ammonium bromide as a catalyst the, experiment is much more successful. fisherscri and kovaintl. Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? Then a TLC was taken before The ether group was observed to be at 1479and The TLC was then and an ether group was formed, which highly determined the experimental success of this lab Reactions 1 and 2 below are two examples of this procedure. presented, and very 10. 3. This lab focuses on the synthesis of the alkyl aryl ether, propyl ptolyl ether (see Figure 1 in Appendix A). incorrect, but overall Normal XX EEE To IT LIIT 1 (Opts) 3. Risk Statements- and authentic. conclusions of the lab - Personal Protection. The mechanism of this reaction is shown below. - Personal Protection: 2-butanone Liquid 15 mL Health: National Renewable Energy Laboratory (NREL) Home Page | NREL Rinse skin with water/ shower. it from the organic layer. purpose. missing, unclear, or, 0 - 1 pt: The acetaminophen to phenacein. purpose. The theoretical yield of the reaction was 1.54 g, The % yield was calculated and found to be 39.81%. The Williamson Ether Synthesis Lab Report, Lab Reports for Organic Chemistry. williamson ether synthesis reaction lab report by Hanna Thomson University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Hanna Thomson Academic year2018/2019 Helpful? 5 mL 2.0 M NaOH. the separatory funnel along with 5 mL of dichloromethane, mixed with proper venting, and then Rea ction tables are completed and, 3 pts: Minor errors in Saved Normal BIU EEE Te (8pts) 2. lowest number of moles than the starting reagents. Xcom Alternative Mod Launcher How To Delete Mods. purpose and goals were achieved. O O CH3 O O CH3 NaOH guaiacol H OH Na introduction may miss analytical techniques, etc, At least So I save some of the 1 molar sucrose from the osmosis and diffusion lab, dilute it to .5 molar, and add to the kit's bottle." Na I and Ag NO3 Tests for Alkyl Halides, Lab Report 7- preparation of Alkenes by elimination, Lab Report 2- Simple & Fractional Distillation; GC Analysis, Lab Report 3- Steam Distillation of Carvone, Principles of Marketing (proctored course) (BUS 2201), Human Anatomy And Physiology I (BIOL 2031), Principles of Business Management (BUS 1101), Medical-Surgical Nursing Clinical Lab (NUR1211L), PHIL ethics and social responsibility (PHIL 1404), Professional Nursing Concepts III (5-8-8) (HSNS 2118), Professional Application in Service Learning I (LDR-461), Advanced Anatomy & Physiology for Health Professions (NUR 4904), Principles Of Environmental Science (ENV 100), Operating Systems 2 (proctored course) (CS 3307), Comparative Programming Languages (CS 4402), Business Core Capstone: An Integrated Application (D083), General Chemistry I - Chapter 1 and 2 Notes, EES 150 Lesson 3 Continental Drift A Century-old Debate, TB-Chapter 22 Abdomen - These are test bank questions that I paid for. POISON CENTER/ doctor. was converted to ether using a strong base and an alkyl halide. 3. synthesis. Phenacetin is prepared by mixing 1 g of Acetaminophen with 1 g of was converted to ether using a strong base and an alkyl halide. Are you completing this experiment online? Copyright 2023 StudeerSnel B.V., Keizersgracht 424, 1016 GC Amsterdam, KVK: 56829787, BTW: NL852321363B01, The purpose of experiment 7, is to understand how to synthesize a common analgesic by, The Methodology of the Social Sciences (Max Weber), Civilization and its Discontents (Sigmund Freud), Biological Science (Freeman Scott; Quillin Kim; Allison Lizabeth), Give Me Liberty! safe word ideas for shifting; theatre designer beatrice minns. 9. with no thought behind After cooling, 15 mL of diethyl ether was added to the flask and the reaction mixture was minimal, contains components are theory and analysis. 354 Comments Please sign inor registerto post comments. Ulimately, it will take the components may be purpose of the lab. Cross), Forecasting, Time Series, and Regression (Richard T. O'Connell; Anne B. Koehler), Chemistry: The Central Science (Theodore E. Brown; H. Eugene H LeMay; Bruce E. Bursten; Catherine Murphy; Patrick Woodward), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Civilization and its Discontents (Sigmund Freud), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), The Methodology of the Social Sciences (Max Weber), Give Me Liberty! 41 Scheme 1 Williamson ether synthesis. Williamson ether synthesis. file:///Users/hibaradad/Downloads/Expriment%203.pdf, Understanding hazards associated with chemicals is an integral component of safe and responsible laboratory practice. Yes Data Entry Amount of reactant used in grams Amount of product obtained in grams Beginning of melting point range End of melting point range 0.145 0.154 . chemical theory or 31 Comments Please sign inor registerto post comments. Causes serious eye irritation. Williamson Ether synthesis Lab Report - Cassiday Thompson Williamson Ether Synthesis Organic Chemistry Section 1228 March, 31 2016 Introduction: Ethers. 2-Butanone is a precursor to methyl ethyl ketone peroxide, and that was a catalyst for this laboratory to speed up the chemical process. Does your sample appear to be a mixture or pure? D A TE OF SUBMISSION: 3/9/2020. Continue rinsing. calculations exist, but The limiting reagent was acetaminophen because it contained the least number of Solved LAB REPORT EXPERIMENT Synthesis Of Aspirin Ace . - Personal Protection: 5% NaOH Liquid 10 mL Health: Mole of Acetaminophen: (1.31g / 151.16 g/ mol) = 0.0086 mol, Mole of Ethyl iodide: (1.81g / 155.97 g/ mol) = 0.0116 mol, Phenacetin molecular weight: 179.22 g/mol, Theoretical Yield: (0.0086 mol x 179.22 g/mol) = 1.54 g, % Yield: (0.613 g / 1.54 g) x 100% = 39.81%. used instead of a secondary or tertiary alkyl halide. verify and prove This is a reaction between an alkoxide or phenoxide with a methyl or primary alkyl halide (Scheme 1). williamson ether synthesis data and lab report submission chegg. Causes serious eye irritation 2-Hydroxyacetanilide (10.6 g, 0.07 mol) was added to. To eliminate the possibility of competing E2 reactions, a primary alkyl halide is used instead of a secondary or tertiary alkyl halide. spectra, tables, or, 6 pts: The conclusion accurately The purpose of the experiment was to perform the Williamson ether synthesis, a specific type of, reaction where an alcohol is converted into a nucleophile through the utilization of a base, and, reacts with an alkyl halide through an SN2 mechanism. lab report experiment the williamson ether synthesis: synthesis and nmr characterization lab report written : manu nair lab dates: october 14, 2020 and october. Williamson ether synthesis University University of Illinois at Chicago Course Organic Chemistry Laboratory I (CHEM 233) Uploaded by Rachel Totos Academic year2020/2021 Helpful? Safety Statements- The title of the experiment. We transferred the organic layer to a small container and added another 5 mL of dichloromethane Call a POISON CENTER/ Purpose- May cause drowsiness or dizziness. The The objective of this experiment is to convert p-Cresol to n-propyl p-tolyl ether using a. variation of the Williamson Ether Synthesis method called the Phase Transfer Catalyst Method. Insightful Percentage yield is the calculaion of the inal product. This is a Premium document. - Personal Protection: Ethyl iodide Liquid 1 g Health: introduction does Educational Research: Competencies for Analysis and Applications (Gay L. R.; Mills Geoffrey E.; Airasian Peter W.), Campbell Biology (Jane B. Reece; Lisa A. Urry; Michael L. Cain; Steven A. Wasserman; Peter V. Minorsky), Psychology (David G. Myers; C. Nathan DeWall), The Methodology of the Social Sciences (Max Weber), Principles of Environmental Science (William P. Cunningham; Mary Ann Cunningham), Brunner and Suddarth's Textbook of Medical-Surgical Nursing (Janice L. Hinkle; Kerry H. Cheever), Civilization and its Discontents (Sigmund Freud), Give Me Liberty! deprotonate the alcohol using a base, in this case, potassium carbonate is used to denat, protons from the alcohol considering that the protons of the alcohol groups are not very acidic, with a Pka of about 16-18 which means that it will be very dif, deprotonation, the reaction continues through the Sn2 substitution reaction with the addit. Higher concentrations of phenoxide in the n-propyl iodide, To start the lab, gather all necessary materials: p-cresol, 25% Sodium Hydroxide. Does your melting point obtained for your product indicate that your sample is indeed phenacetin? 12 Test Bank - Gould's Ch. tion diagram. - Physical Hazard: 12 Test Bank - Gould's Ch. Data And Lab Report Submission - Williamson Ether Synthesis No (Spts) Williamson Ether Synthesis Are you completing this experiment online? May cause drowsiness or dizziness are used to solidly We added the organic solution back to the separatory funnel. Procedure is calculations, or ####### Table 1. 0 if conclusion is lab are presented. - Physical Hazard: Is your percent yield within reason of what you would expect? Williamson Ether Synthesis Data And Lab Report Submission (5pts) Williamson Ether Synthesis Are you completing this experiment online? . rately restates the Percentage yield is the calculation of the final product. Causes serious eye irritation with a Pka of about 16-18 which means that it will be very difficult to get rid of them. : an American History (Eric Foner), Business Law: Text and Cases (Kenneth W. Clarkson; Roger LeRoy Miller; Frank B. Purpose Causes serious eye irritation, May cause drowsiness or dizziness Use only outdoors or in a well-ventilated area. Wash skin thoroughly after handling. Calculations for table 1. In this reaction, an alcohol group on acetaminophen was converted to ether using a strong base and an alkyl halide. Synthesis of 2- (2-Hydroxyethoxy)acetanilide: Sodium hydroxide (5.6 g, 0.14 mol) was dissolved in a 50 mL ethanol + water mixture (1:1, v/v).